Jutta Grum

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Dutasteride vs. finasteride

The efficacy of dutasteride, finasteride and placebo were examined in a study conducted under the most stringent clinical-scientific conditions by Olsen et al. The study (also called JAAD study) was published in the Journal of the American Academy of Dermatology (JAAD).

The JAAD study

A total of 416 men (25-46 years of age) with hair loss took part in the study and were treated for 12 and 24 weeks.

It turned out that dutasteride (2.5 mg) has a much better effect for the growth of hair on the affected areas of the scalp in comparison with finasteride (5 mg). The number of hairs increases by nearly threefold.

The difference between dutasteride and finasteride is that dutasteride inhibits type 1 as well as type 2 5-alpha reductase, whereas finasteride only inhibits type 2. Both forms of the enzyme transform testosterone into DHT. A high DHT level is the main cause of hair loss.

After only two weeks dutasteride lowers the DHT level by 90%, whereas finasteride only lowers the DHT level by 70%. The concentration of the circulating testosterone androgen in the plasma remains the same or increases slightly in both cases. Avodart® is consequently a very effective medication against hair loss and BPH (benign prostatic hyperplasia).

 


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Hair Loss


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