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Dutasteride vs. finasteride
The efficacy of dutasteride, finasteride and placebo were examined in a study conducted under the most stringent clinical-scientific conditions by Olsen et al. The study (also called JAAD study) was published in the Journal of the American Academy of Dermatology (JAAD).
The JAAD study
A total of 416 men (25-46 years of age) with hair loss took part in the study and were treated for 12 and 24 weeks.
- Dutasteride: 0.05 mg, 0.1 mg, 0.5 mg and 2.5 mg
- Finasteride: 5 mg
It turned out that dutasteride (2.5 mg) has a much better effect for the growth of hair on the affected areas of the scalp in comparison with finasteride (5 mg). The number of hairs increases by nearly threefold.
- Placebo: 32.5 hairs
- Finasteride (5 mg): 75.6 hairs
- Dutasteride (0,5 mg): 94.6 hairs
- Dutasteride (2.5 mg ): 109.6 hairs
The difference between dutasteride and finasteride is that dutasteride inhibits type 1 as well as type 2 5-alpha reductase, whereas finasteride only inhibits type 2. Both forms of the enzyme transform testosterone into DHT. A high DHT level is the main cause of hair loss.
After only two weeks dutasteride lowers the DHT level by 90%, whereas finasteride only lowers the DHT level by 70%. The concentration of the circulating testosterone androgen in the plasma remains the same or increases slightly in both cases. Avodart® is consequently a very effective medication against hair loss and BPH (benign prostatic hyperplasia).